For research use only. Not for therapeutic Use.
Govorestat (Cat No.:I017780) is a potent, selective inhibitor of aldose reductase, the first enzyme in the polyol pathway that converts glucose to sorbitol. Excess sorbitol accumulation is linked to oxidative stress, cellular damage, and complications in metabolic and neurological diseases. By blocking this pathway, Govorestat reduces toxic metabolite buildup and protects against tissue injury. It is under investigation for treating rare metabolic disorders such as galactosemia and certain neuropathies. Govorestat’s strong target engagement and favorable pharmacokinetics make it a promising therapeutic candidate in metabolic disease research.
| CAS Number | 2170729-29-8 |
| Synonyms | 2-[4-oxo-3-[[5-(trifluoromethyl)-1,3-benzothiazol-2-yl]methyl]thieno[3,4-d]pyridazin-1-yl]acetic acid |
| Molecular Formula | C17H10F3N3O3S2 |
| Purity | ≥95% |
| IUPAC Name | 2-[4-oxo-3-[[5-(trifluoromethyl)-1,3-benzothiazol-2-yl]methyl]thieno[3,4-d]pyridazin-1-yl]acetic acid |
| InChI | InChI=1S/C17H10F3N3O3S2/c18-17(19,20)8-1-2-13-12(3-8)21-14(28-13)5-23-16(26)10-7-27-6-9(10)11(22-23)4-15(24)25/h1-3,6-7H,4-5H2,(H,24,25) |
| InChIKey | ORQGHAJIWGGFJK-UHFFFAOYSA-N |
| SMILES | C1=CC2=C(C=C1C(F)(F)F)N=C(S2)CN3C(=O)C4=CSC=C4C(=N3)CC(=O)O |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
