Golotimod hydrochloride

• CAT Number: I046102
• CAS Number: 1029401-59-9
• Molecular Formula: C16H20ClN3O5
• Molecular Weight: 369.80
• Purity: ≥95%
• Synonyms: (2R)-2-amino-5-[[(1S)-1-carboxy-2-(1H-indol-3-yl)ethyl]amino]-5-oxopentanoic acid;hydrochloride
• IUPAC Name: (2R)-2-amino-5-[[1-carboxy-2-(1H-indol-3-yl)ethyl]amino]-5-oxopentanoic acid;hydrochloride
• InChI: InChI=1S/C16H19N3O5.ClH/c17-11(15(21)22)5-6-14(20)19-13(16(23)24)7-9-8-18-12-4-2-1-3-10(9)12;/h1-4,8,11,13,18H,5-7,17H2,(H,19,20)(H,21,22)(H,23,24);1H/t11-,13?;/m1./s1
• InChIKey: YYTBHYZPAMPQGT-ZRMPQGGQSA-N
• SMILES: C1=CC=C2C(=C1)C(=CN2)CC(C(=O)O)NC(=O)CC[C@H](C(=O)O)N.Cl

Golotimod hydrochloride（Cat No.:I046102）is an immunomodulatory agent belonging to the thiazolyl peptide class. It acts as a toll-like receptor 2 (TLR2) agonist, stimulating innate immune responses and enhancing cytokine production, including TNF-α and IL-6. Initially developed as an oral therapy for cancer and infectious diseases, Golotimod was studied for its ability to boost antitumor immunity and augment host defense mechanisms. Although clinical development faced limitations, its mechanism highlights the therapeutic potential of TLR2 modulators. Golotimod hydrochloride remains valuable in immunology and oncology research as a tool compound.