For research use only. Not for therapeutic Use.
GNF362(Cat No.:I017832)is a selective small-molecule antagonist of the thyroid-stimulating hormone receptor (TSHR), developed to explore therapeutic approaches for hyperthyroidism and Graves’ disease. By blocking TSHR signaling, GNF362 reduces cyclic AMP production and downstream thyroid hormone synthesis, thereby dampening overactive thyroid function. In preclinical studies, it has shown efficacy in suppressing thyroid-stimulating autoantibody–induced signaling, making it a valuable candidate for autoimmune thyroid disorders. Researchers use GNF362 to investigate thyroid biology, receptor pharmacology, and novel strategies for managing endocrine diseases associated with TSHR overactivation.
CAS Number | 1003019-41-7 |
Synonyms | 4-[4-[[(3R)-3-methyl-4-[5-(trifluoromethyl)pyridin-2-yl]piperazin-1-yl]methyl]-1H-pyrazol-5-yl]benzonitrile |
Molecular Formula | C22H21F3N6 |
Purity | ≥95% |
IUPAC Name | 4-[4-[[(3R)-3-methyl-4-[5-(trifluoromethyl)-2-pyridinyl]piperazin-1-yl]methyl]-1H-pyrazol-5-yl]benzonitrile |
InChI | InChI=1S/C22H21F3N6/c1-15-13-30(8-9-31(15)20-7-6-19(12-27-20)22(23,24)25)14-18-11-28-29-21(18)17-4-2-16(10-26)3-5-17/h2-7,11-12,15H,8-9,13-14H2,1H3,(H,28,29)/t15-/m1/s1 |
InChIKey | VNTCGXMLDSKOKN-OAHLLOKOSA-N |
SMILES | C[C@@H]1CN(CCN1C2=NC=C(C=C2)C(F)(F)F)CC3=C(NN=C3)C4=CC=C(C=C4)C#N |
Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |