For research use only. Not for therapeutic Use.
GNF2133（Cat No.:I045212）is a potent, selective inhibitor of colony-stimulating factor 1 receptor (CSF1R), a receptor tyrosine kinase critical for the survival, proliferation, and differentiation of macrophages and microglia. By blocking CSF1R signaling, GNF2133 reduces macrophage-mediated inflammation and modulates tumor-associated macrophage activity within the tumor microenvironment. It is a valuable research tool for studying immune regulation, neuroinflammation, and cancer immunology. GNF2133 holds therapeutic potential for treating inflammatory diseases, neurodegenerative disorders, and cancers where CSF1R-driven macrophage activity plays a key role in disease progression and immune evasion.
| CAS Number | 2561414-56-8 |
| Synonyms | 4-ethyl-N-[4-[1-(oxan-4-yl)pyrrolo[2,3-c]pyridin-3-yl]pyridin-2-yl]piperazine-1-carboxamide |
| Molecular Formula | C24H30N6O2 |
| Purity | ≥95% |
| IUPAC Name | 4-ethyl-N-[4-[1-(oxan-4-yl)pyrrolo[2,3-c]pyridin-3-yl]pyridin-2-yl]piperazine-1-carboxamide |
| InChI | InChI=1S/C24H30N6O2/c1-2-28-9-11-29(12-10-28)24(31)27-23-15-18(3-8-26-23)21-17-30(19-5-13-32-14-6-19)22-16-25-7-4-20(21)22/h3-4,7-8,15-17,19H,2,5-6,9-14H2,1H3,(H,26,27,31) |
| InChIKey | SAZIAQSVBIWIDU-UHFFFAOYSA-N |
| SMILES | CCN1CCN(CC1)C(=O)NC2=NC=CC(=C2)C3=CN(C4=C3C=CN=C4)C5CCOCC5 |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
