For research use only. Not for therapeutic Use.
GNE-987(CAT: I046040) is a highly potent, bifunctional PROTAC that recruits von Hippel–Lindau (VHL) to BRD4 for targeted protein degradation. Incorporating a BET inhibitor, a VHL ligand, and a ten-methylene spacer, it achieves rapid, selective BRD4 depletion with picomolar potency (DC₅₀ = 0.03 nM in EOL-1 AML cells). GNE-987 binds BD1 and BD2 bromodomains equipotently (IC₅₀ = 4.7 and 4.4 nM), suppresses MYC expression, and reduces EOL-1 and HL-60 viability with IC₅₀s of 0.02–0.03 nM. At nanomolar concentrations, it also degrades BRD2 and BRD3, making it a powerful probe for BET biology and PROTAC-antibody conjugate (PAC) development.
| CAS Number | 2417371-71-0 |
| Synonyms | 8-(3,5-difluoropyridin-2-yl)-N-[11-[[(2S)-1-[(2S,4R)-4-hydroxy-2-[[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methylcarbamoyl]pyrrolidin-1-yl]-3,3-dimethyl-1-oxobutan-2-yl]amino]-11-oxoundecyl]-15-methyl-4-(methylsulfonylmethyl)-14-oxo-8,12,15-triazatetracyclo[8.6.1.02,7.013,17]heptadeca-1(16),2(7),3,5,10,13(17)-hexaene-5-carboxamide |
| Molecular Formula | C56H67F2N9O8S2 |
| Purity | ≥95% |
| IUPAC Name | 8-(3,5-difluoropyridin-2-yl)-N-[11-[[(2S)-1-[(2S,4R)-4-hydroxy-2-[[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methylcarbamoyl]pyrrolidin-1-yl]-3,3-dimethyl-1-oxobutan-2-yl]amino]-11-oxoundecyl]-15-methyl-4-(methylsulfonylmethyl)-14-oxo-8,12,15-triazatetracyclo[8.6.1.02,7.013,17]heptadeca-1(16),2(7),3,5,10,13(17)-hexaene-5-carboxamide |
| InChI | InChI=1S/C56H67F2N9O8S2/c1-33-49(76-32-63-33)35-18-16-34(17-19-35)25-62-53(71)45-23-39(68)29-67(45)55(73)50(56(2,3)4)64-46(69)15-13-11-9-7-8-10-12-14-20-59-52(70)40-24-44-41(21-36(40)31-77(6,74)75)42-30-65(5)54(72)48-47(42)37(26-60-48)28-66(44)51-43(58)22-38(57)27-61-51/h16-19,21-22,24,26-27,30,32,39,45,50,60,68H,7-15,20,23,25,28-29,31H2,1-6H3,(H,59,70)(H,62,71)(H,64,69)/t39-,45+,50-/m1/s1 |
| InChIKey | VTPSYVSGGUUAFN-GDNJTPAESA-N |
| SMILES | CC1=C(SC=N1)C2=CC=C(C=C2)CNC(=O)C3CC(CN3C(=O)C(C(C)(C)C)NC(=O)CCCCCCCCCCNC(=O)C4=CC5=C(C=C4CS(=O)(=O)C)C6=CN(C(=O)C7=C6C(=CN7)CN5C8=C(C=C(C=N8)F)F)C)O |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
