For research use only. Not for therapeutic Use.
GNE-618（Cat No.:I017868）is a potent small-molecule inhibitor of nicotinamide phosphoribosyltransferase (NAMPT), the key enzyme in the NAD⁺ salvage pathway. By blocking NAMPT activity, GNE-618 depletes intracellular NAD⁺ levels, leading to impaired energy metabolism and apoptosis, particularly in rapidly proliferating cancer cells. This compound is a valuable research tool for studying cancer metabolism, redox biology, and stress response pathways. GNE-618 has demonstrated strong antitumor activity in preclinical models, supporting its role in exploring metabolic vulnerabilities and the therapeutic potential of targeting NAD⁺ biosynthesis.
| CAS Number | 1362151-42-5 |
| Synonyms | N-[[4-[3-(trifluoromethyl)phenyl]sulfonylphenyl]methyl]-1H-pyrazolo[3,4-b]pyridine-5-carboxamide |
| Molecular Formula | C21H15F3N4O3S |
| Purity | ≥95% |
| IUPAC Name | N-[[4-[3-(trifluoromethyl)phenyl]sulfonylphenyl]methyl]-1H-pyrazolo[3,4-b]pyridine-5-carboxamide |
| InChI | InChI=1S/C21H15F3N4O3S/c22-21(23,24)16-2-1-3-18(9-16)32(30,31)17-6-4-13(5-7-17)10-26-20(29)15-8-14-12-27-28-19(14)25-11-15/h1-9,11-12H,10H2,(H,26,29)(H,25,27,28) |
| InChIKey | LKBHAGGICJWHQQ-UHFFFAOYSA-N |
| SMILES | C1=CC(=CC(=C1)S(=O)(=O)C2=CC=C(C=C2)CNC(=O)C3=CN=C4C(=C3)C=NN4)C(F)(F)F |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
