GNE-1858

• CAT Number: I045951
• CAS Number: 2680616-96-8
• Molecular Formula: C21H26F2N8
• Molecular Weight: 428.48
• Purity: ≥95%
• Synonyms: N-[2-(3,3-difluoropyrrolidin-1-yl)-6-pyrrolidin-3-ylpyrimidin-4-yl]-1-propan-2-ylpyrazolo[4,3-c]pyridin-6-amine
• InChI: InChI=1S/C21H26F2N8/c1-13(2)31-17-8-18(25-10-15(17)11-26-31)28-19-7-16(14-3-5-24-9-14)27-20(29-19)30-6-4-21(22,23)12-30/h7-8,10-11,13-14,24H,3-6,9,12H2,1-2H3,(H,25,27,28,29)
• InChIKey: JKPAJCPZQIJPPS-UHFFFAOYSA-N
• SMILES: CC(C)N1C2=CC(=NC=C2C=N1)NC3=NC(=NC(=C3)C4CCNC4)N5CCC(C5)(F)F

GNE-1858（Cat No.:I045951）is a selective, small-molecule inhibitor of the receptor tyrosine kinase RET, developed to study oncogenic RET-driven signaling. RET alterations, including fusions and activating mutations, are implicated in thyroid cancers, non-small cell lung cancer, and other malignancies. By blocking RET kinase activity, GNE-1858 suppresses downstream MAPK and PI3K/AKT pathways, providing a valuable tool for investigating tumor growth and survival mechanisms. This compound supports oncology research, target validation, and drug discovery efforts focused on RET-dependent cancers, offering insights into therapeutic strategies against RET-mediated malignancies.