For research use only. Not for therapeutic Use.
GNE-0439（Cat No.:I018141）is a potent, selective small-molecule inhibitor of FGFR (fibroblast growth factor receptor) kinases, designed to block aberrant FGFR-driven signaling in cancer. By binding to the ATP-binding site, GNE-0439 suppresses downstream MAPK and PI3K/AKT pathways, inhibiting tumor cell proliferation and survival. It demonstrates strong activity against FGFR-altered malignancies, including those with gene fusions, amplifications, or activating mutations. Researchers use GNE-0439 as a tool to investigate FGFR biology, resistance mechanisms, and therapeutic targeting. This compound supports preclinical studies exploring precision oncology strategies.
| CAS Number | 1241902-40-8 |
| Synonyms | (2S)-3-methyl-2-[[4-(4-propylcyclohexyl)benzoyl]amino]butanoic acid |
| Molecular Formula | C21H31NO3 |
| Purity | ≥95% |
| IUPAC Name | (2S)-3-methyl-2-[[4-(4-propylcyclohexyl)benzoyl]amino]butanoic acid |
| InChI | InChI=1S/C21H31NO3/c1-4-5-15-6-8-16(9-7-15)17-10-12-18(13-11-17)20(23)22-19(14(2)3)21(24)25/h10-16,19H,4-9H2,1-3H3,(H,22,23)(H,24,25)/t15?,16?,19-/m0/s1 |
| InChIKey | SKMKUWKJBZSEJH-RJYAGPCLSA-N |
| SMILES | CCCC1CCC(CC1)C2=CC=C(C=C2)C(=O)N[C@@H](C(C)C)C(=O)O |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
