Gly-Gly-Phe-Gly

• CAT Number: I042537
• CAS Number: 200427-88-9
• Molecular Formula: C15H20N4O5
• Molecular Weight: 336.34
• Purity: ≥95%
• Synonyms: 2-[[(2S)-2-[[2-[(2-aminoacetyl)amino]acetyl]amino]-3-phenylpropanoyl]amino]acetic acid
• InChI: InChI=1S/C15H20N4O5/c16-7-12(20)17-8-13(21)19-11(15(24)18-9-14(22)23)6-10-4-2-1-3-5-10/h1-5,11H,6-9,16H2,(H,17,20)(H,18,24)(H,19,21)(H,22,23)/t11-/m0/s1
• InChIKey: HXUVTXPOZRFMOY-NSHDSACASA-N
• SMILES: C1=CC=C(C=C1)CC(C(=O)NCC(=O)O)NC(=O)CNC(=O)CN

Gly-Gly-Phe-Gly (Cat No.: I042537) is a tetrapeptide composed of glycine (Gly), phenylalanine (Phe), and another glycine residue, forming the sequence Gly-Gly-Phe-Gly. It is frequently used in biochemical and enzymatic studies, particularly as a substrate or model sequence for investigating protease specificity and activity, such as with chymotrypsin and other serine proteases. The phenylalanine residue provides an aromatic side chain that enhances interaction with hydrophobic active sites. This peptide is valuable for studying peptide cleavage, enzymatic kinetics, and protein engineering applications.

Reference

[1]. Shiose Y, et al. Systematic research of peptide spacers controlling drug release from macromolecular prodrug system, carboxymethyldextran polyalcohol-peptide-drug conjugates. Bioconjug Chem. 2009 Jan;20(1):60-70.
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