Glutathione synthesis-IN-1

• CAT Number: I044036
• CAS Number: 2632968-72-8
• Molecular Formula: C21H16O3
• Molecular Weight: 316.35
• Purity: ≥95%
• Synonyms: 2-hydroxy-5-[(E)-2-(4-phenylphenyl)ethenyl]benzoic acid
• InChI: InChI=1S/C21H16O3/c22-20-13-10-16(14-19(20)21(23)24)7-6-15-8-11-18(12-9-15)17-4-2-1-3-5-17/h1-14,22H,(H,23,24)/b7-6+
• InChIKey: PTIOBWXSSXHDCF-VOTSOKGWSA-N
• SMILES: C1=CC=C(C=C1)C2=CC=C(C=C2)/C=C/C3=CC(=C(C=C3)O)C(=O)O

Glutathione Synthesis-IN-1（Cat No.:I044036）is a selective inhibitor of glutamate-cysteine ligase (GCL), the rate-limiting enzyme in glutathione (GSH) biosynthesis. By targeting GCL, this compound effectively reduces intracellular GSH levels, impairing cellular antioxidant defenses and sensitizing cells to oxidative stress. Glutathione Synthesis-IN-1 is a valuable research tool for studying redox homeostasis, ferroptosis, and the role of GSH in cancer, neurodegeneration, and immune responses. It facilitates investigation into the therapeutic potential of modulating glutathione pathways, particularly in diseases where oxidative imbalance and resistance to oxidative damage are central to pathophysiology.