Glutarimide-Isoindolinone-NH-PEG3-COOH

• CAT Number: I044475
• CAS Number: 2803819-65-8
• Molecular Formula: C22H29N3O8
• Molecular Weight: 463.48
• Purity: ≥95%
• Synonyms: 3-[2-[2-[2-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]amino]ethoxy]ethoxy]ethoxy]propanoic acid
• InChI: InChI=1S/C22H29N3O8/c26-19-4-3-18(21(29)24-19)25-14-15-13-16(1-2-17(15)22(25)30)23-6-8-32-10-12-33-11-9-31-7-5-20(27)28/h1-2,13,18,23H,3-12,14H2,(H,27,28)(H,24,26,29)
• InChIKey: HYRLBRBJUKIXJO-UHFFFAOYSA-N
• SMILES: C1CC(=O)NC(=O)C1N2CC3=C(C2=O)C=CC(=C3)NCCOCCOCCOCCC(=O)O

Glutarimide-Isoindolinone-NH-PEG3-COOH（Cat No.:I044475）is a functionalized cereblon (CRBN)-binding ligand used in the design of PROTACs (proteolysis-targeting chimeras). It contains a glutarimide-isoindolinone core structure that mimics the binding motif of thalidomide, enabling high-affinity recruitment of CRBN, a substrate receptor of the CRL4 E3 ubiquitin ligase complex. The PEG3 (triethylene glycol) linker provides enhanced solubility, flexibility, and optimal spatial orientation for effective target engagement. The terminal carboxylic acid group facilitates conjugation to a ligand specific for a target protein, making this compound a versatile tool in chemical biology and drug discovery focused on targeted protein degradation.