Glutarimide-Isoindolinone-NH-PEG2-COOH

• CAT Number: I044474
• CAS Number: 2803827-03-2
• Molecular Formula: C20H25N3O7
• Molecular Weight: 419.43
• Purity: ≥95%
• Synonyms: 3-[2-[2-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]amino]ethoxy]ethoxy]propanoic acid
• InChI: InChI=1S/C20H25N3O7/c24-17-4-3-16(19(27)22-17)23-12-13-11-14(1-2-15(13)20(23)28)21-6-8-30-10-9-29-7-5-18(25)26/h1-2,11,16,21H,3-10,12H2,(H,25,26)(H,22,24,27)
• InChIKey: OLXWGGOWRQJBRT-UHFFFAOYSA-N
• SMILES: C1CC(=O)NC(=O)C1N2CC3=C(C2=O)C=CC(=C3)NCCOCCOCCC(=O)O

Glutarimide-Isoindolinone-NH-PEG2-COOH（Cat No.:I044474）is a bifunctional chemical scaffold commonly used in the synthesis of PROTACs (proteolysis-targeting chimeras). It features a glutarimide-isoindolinone core, which mimics the thalidomide pharmacophore and binds to cereblon (CRBN), a substrate receptor of the CRL4 E3 ubiquitin ligase complex. The PEG2 (polyethylene glycol dimer) linker enhances solubility and flexibility, while the terminal carboxylic acid group allows for conjugation to ligands targeting proteins of interest. This compound enables the development of cereblon-recruiting degraders, supporting research into targeted protein degradation and novel therapeutic strategies for cancer and other diseases.