For research use only. Not for therapeutic Use.
Glucosylsphingosine (Cat No.: R054752) is a bioactive lipid and the deacylated form of glucosylceramide, consisting of a sphingosine backbone linked to a glucose molecule. It accumulates abnormally in Gaucher disease due to deficient activity of the enzyme glucocerebrosidase. Elevated levels are associated with disease pathology, making it a key biomarker for diagnosis and monitoring. Glucosylsphingosine is also studied for its role in inflammation, immune activation, and neuronal dysfunction, contributing to research in lysosomal storage disorders and neurodegenerative diseases.
| CAS Number | 52050-17-6 |
| Synonyms | (2R,3R,4S,5S,6R)-2-[(E,2S,3R)-2-amino-3-hydroxyoctadec-4-enoxy]-6-(hydroxymethyl)oxane-3,4,5-triol |
| Molecular Formula | C24H47NO7 |
| Purity | ≥95% |
| InChI | InChI=1S/C24H47NO7/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-19(27)18(25)17-31-24-23(30)22(29)21(28)20(16-26)32-24/h14-15,18-24,26-30H,2-13,16-17,25H2,1H3/b15-14+/t18-,19+,20+,21+,22-,23+,24+/m0/s1 |
| InChIKey | HHJTWTPUPVQKNA-JIAPQYILSA-N |
| SMILES | CCCCCCCCCCCCCC=CC(C(COC1C(C(C(C(O1)CO)O)O)O)N)O |
| Reference | [1]. Hurvitz N, et al. Glucosylsphingosine (lyso-Gb1) as a Biomarker for Monitoring Treated and Untreated Children with Gaucher Disease. Int J Mol Sci. 2019 Jun 21;20(12):3033. |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
