Glucosylceramide synthase-IN-2

• CAT Number: I044059
• CAS Number: 2597958-02-4
• Molecular Formula: C22H20F3N3O4
• Molecular Weight: 447.41
• Purity: ≥95%
• Synonyms: N-[4-(2-hydroxypropan-2-yl)phenyl]-3-oxo-2-[2-(2,2,2-trifluoroethoxy)phenyl]pyridazine-4-carboxamide
• InChI: InChI=1S/C22H20F3N3O4/c1-21(2,31)14-7-9-15(10-8-14)27-19(29)16-11-12-26-28(20(16)30)17-5-3-4-6-18(17)32-13-22(23,24)25/h3-12,31H,13H2,1-2H3,(H,27,29)
• InChIKey: CQAPXPSWLDAVEG-UHFFFAOYSA-N
• SMILES: CC(C)(C1=CC=C(C=C1)NC(=O)C2=CC=NN(C2=O)C3=CC=CC=C3OCC(F)(F)F)O

Glucosylceramide Synthase-IN-2（Cat No.:I044059）is a potent and selective inhibitor of glucosylceramide synthase (GCS), the enzyme responsible for catalyzing the first step in glycosphingolipid biosynthesis by converting ceramide to glucosylceramide. By blocking GCS activity, this compound reduces the accumulation of glycosphingolipids, which are implicated in lysosomal storage disorders such as Gaucher and Fabry diseases. It is also valuable in cancer and metabolic disease research, where glycosphingolipid metabolism influences cell signaling and drug resistance. Glucosylceramide Synthase-IN-2 enables the exploration of therapeutic strategies targeting sphingolipid pathways to restore cellular balance and treat related pathologies.