Glucocorticoid receptor modulator 1

• CAT Number: I042388
• CAS Number: 2868357-11-1
• Molecular Formula: C24H23ClN2O4S
• Molecular Weight: 470.97
• Purity: ≥95%
• Synonyms: N-(1-benzoyl-3,4-dihydro-2H-quinolin-6-yl)-5-chloro-2-methoxy-4-methylbenzenesulfonamide
• InChI: InChI=1S/C24H23ClN2O4S/c1-16-13-22(31-2)23(15-20(16)25)32(29,30)26-19-10-11-21-18(14-19)9-6-12-27(21)24(28)17-7-4-3-5-8-17/h3-5,7-8,10-11,13-15,26H,6,9,12H2,1-2H3
• InChIKey: BDARZHMPJRWQLB-UHFFFAOYSA-N
• SMILES: CC1=CC(=C(C=C1Cl)S(=O)(=O)NC2=CC3=C(C=C2)N(CCC3)C(=O)C4=CC=CC=C4)OC

Glucocorticoid Receptor Modulator 1 (Cat No.: I042388) is a synthetic compound that selectively modulates the glucocorticoid receptor (GR), offering tissue- or gene-specific regulation of GR-mediated responses. Unlike full agonists, modulators like this can fine-tune GR activity to preserve anti-inflammatory efficacy while minimizing side effects such as metabolic disruption or bone loss. It is widely studied in models of inflammation, autoimmune disease, and cancer. This compound serves as a valuable tool for developing next-generation glucocorticoid therapies with improved safety and therapeutic profiles.

Reference

[1]. Li D, Hou T, et al. Discovery and Optimization of N-Acyl-6-sulfonamide-tetrahydroquinoline Derivatives as Novel Non-Steroidal Selective Glucocorticoid Receptor Modulators. J Med Chem. 2022 Nov 18.
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