Glucocorticoid receptor agonist-2

• CAT Number: I042473
• CAS Number: 2166378-92-1
• Molecular Formula: C34H35F2NO7
• Molecular Weight: 607.64
• Purity: ≥95%
• Synonyms: (1S,2S,4R,6R,8S,9S,11S,12R,13S,19S)-6-[4-(3-aminophenoxy)phenyl]-12,19-difluoro-11-hydroxy-8-(2-hydroxyacetyl)-9,13-dimethyl-5,7-dioxapentacyclo[10.8.0.02,9.04,8.013,18]icosa-14,17-dien-16-one
• InChI: InChI=1S/C34H35F2NO7/c1-31-11-10-20(39)13-25(31)26(35)14-24-23-15-29-34(28(41)17-38,32(23,2)16-27(40)33(24,31)36)44-30(43-29)18-6-8-21(9-7-18)42-22-5-3-4-19(37)12-22/h3-13,23-24,26-27,29-30,38,40H,14-17,37H2,1-2H3/t23-,24-,26-,27-,29+,30+,31-,32-,33-,34+/m0/s1
• InChIKey: LCDCPIOGHJGDBP-APTODLHGSA-N
• SMILES: CC12CC(C3(C(C1CC4C2(OC(O4)C5=CC=C(C=C5)OC6=CC=CC(=C6)N)C(=O)CO)CC(C7=CC(=O)C=CC73C)F)F)O

Glucocorticoid Receptor Agonist-2 (Cat No.: I042473) is a synthetic small-molecule compound that selectively activates the glucocorticoid receptor (GR), a nuclear receptor involved in regulating inflammation, immune responses, and metabolism. Upon binding, it modulates gene transcription to exert anti-inflammatory and immunosuppressive effects. This agonist is used in research to study GR-mediated signaling pathways and assess potential therapeutic effects in diseases such as asthma, autoimmune disorders, and inflammatory conditions. Its selectivity helps explore improved treatments with fewer side effects compared to traditional corticosteroids.

Reference

[1]. Mcpherson MJ, et al. Preparation of glucocorticoid receptor agonist and immunoconjugates thereof. WO2017210471. 2017.