For research use only. Not for therapeutic Use.
Glucocorticoid receptor agonist-1 (Cat No.: I045425) is a synthetic small molecule that selectively binds and activates the glucocorticoid receptor (GR), a nuclear receptor regulating genes involved in inflammation, immune response, and metabolism. Upon activation, it modulates transcription of anti-inflammatory and immunosuppressive proteins while inhibiting pro-inflammatory cytokines. This compound is used in research to study GR-mediated signaling pathways, evaluate anti-inflammatory drug potential, and explore therapeutic applications in autoimmune diseases, asthma, and allergies, with the aim of achieving efficacy while minimizing corticosteroid-associated side effects.
CAS Number | 2166375-82-0 |
Synonyms | (1S,2S,4R,6R,8S,9S,11S,12S,13R)-6-[4-[(3-aminophenyl)methyl]phenyl]-11-hydroxy-8-(2-hydroxyacetyl)-9,13-dimethyl-5,7-dioxapentacyclo[10.8.0.02,9.04,8.013,18]icosa-14,17-dien-16-one |
Molecular Formula | C35H39NO6 |
Purity | ≥95% |
InChI | InChI=1S/C35H39NO6/c1-33-13-12-25(38)16-23(33)10-11-26-27-17-30-35(29(40)19-37,34(27,2)18-28(39)31(26)33)42-32(41-30)22-8-6-20(7-9-22)14-21-4-3-5-24(36)15-21/h3-9,12-13,15-16,26-28,30-32,37,39H,10-11,14,17-19,36H2,1-2H3/t26-,27-,28-,30+,31+,32+,33-,34-,35+/m0/s1 |
InChIKey | MPEPSOPXQDGEHP-WWBNNTNKSA-N |
SMILES | CC12CC(C3C(C1CC4C2(OC(O4)C5=CC=C(C=C5)CC6=CC(=CC=C6)N)C(=O)CO)CCC7=CC(=O)C=CC37C)O |
Reference | [1]. Michael J. Mcpherson, et al. Glucocorticoid receptor agonist and immunoconjugates thereof. WO2017210471A1. |
Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |