For research use only. Not for therapeutic Use.
GLPG2938（Cat No.:I028091）is a selective and potent inhibitor of autotaxin (ATX), an enzyme responsible for converting lysophosphatidylcholine (LPC) into lysophosphatidic acid (LPA), a bioactive lipid involved in inflammation, fibrosis, and cancer. By inhibiting ATX activity, GLPG2938 reduces LPA production and downstream signaling through LPA receptors, thereby modulating processes such as cell proliferation, migration, and survival. It is particularly valuable in research related to idiopathic pulmonary fibrosis (IPF), systemic sclerosis, and other fibrotic or inflammatory conditions. GLPG2938 supports therapeutic development targeting the ATX-LPA axis in chronic disease models.
| CAS Number | 2130996-00-6 |
| Synonyms | 1-[2-ethoxy-6-(trifluoromethyl)pyridin-4-yl]-3-[[5-methyl-6-[1-methyl-3-(trifluoromethyl)pyrazol-4-yl]pyridazin-3-yl]methyl]urea |
| Molecular Formula | C20H19F6N7O2 |
| Purity | ≥95% |
| IUPAC Name | 1-[2-ethoxy-6-(trifluoromethyl)pyridin-4-yl]-3-[[5-methyl-6-[1-methyl-3-(trifluoromethyl)pyrazol-4-yl]pyridazin-3-yl]methyl]urea |
| InChI | InChI=1S/C20H19F6N7O2/c1-4-35-15-7-11(6-14(29-15)19(21,22)23)28-18(34)27-8-12-5-10(2)16(31-30-12)13-9-33(3)32-17(13)20(24,25)26/h5-7,9H,4,8H2,1-3H3,(H2,27,28,29,34) |
| InChIKey | MGJMUVKYINFAQC-UHFFFAOYSA-N |
| SMILES | CCOC1=CC(=CC(=N1)C(F)(F)F)NC(=O)NCC2=NN=C(C(=C2)C)C3=CN(N=C3C(F)(F)F)C |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
