GLP-1(7-37)

  • CAT Number: P000029
  • CAS Number: 106612-94-6
  • Molecular Formula: C151H228N40O47
  • Molecular Weight: 3355.67
  • Purity: 98%
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<p>
GLP-1(7-37) (CAS 106612-94-6)&nbsp;is an insulinotropic peptide generated from the precursor peptide GLP-1(1-37).<br />
target: GLP-1 receptor<br />
IC50:0.31 &plusmn; 0.01nM(Binding experiments with RIN T3 membranes)<br />
EC50:0.9 &plusmn; 0.1nM(RIN T3 cells cyclic AMP Production)<br />
In vitro: After ingestion of a meal, the truncated bioactive sequences GLP-1(7-37) is secreted by the L cells of the intestinal mucosa.it has EC50 of 0.9 &plusmn; 0.1nM when test the RIN T3 cells cyclic AMP production;Besides,it has IC50 of 0.31 &plusmn; 0.01nM for the binding experiments with RIN T3 membranes.</p>

Catalog Number P000029
CAS Number 106612-94-6
Molecular Formula

C151H228N40O47

Purity 98
Target GLP-1 receptor
Solubility H2O
Storage Store at -20°C
SMILES O=C(N[C@@H](C)C(N[C@@H](CCC(O)=O)C(NCC(N[C@@H]([C@H](O)C)C(N[C@@H](CC1=CC=CC=C1)C(N[C@@H]([C@H](O)C)C(N[C@@H](CO)C(N[C@@H](CC(O)=O)C(N[C@@H](C(C)C)C(N[C@@H](CO)C(N[C@@H](CO)C(N[C@@H](CC2=CC=C(C=C2)O)C(N[C@@H](CC(C)C)C(N[C@@H](CCC(O)=O)C(NCC(N[C@@H](CCC(N)
Reference

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<span style="/font-family:Arial;font-size:14px;/">3: Andoh T. Amino acids are more important insulinotropins than glucose in a teleost fish, barfin flounder (Verasper moseri). Gen Comp Endocrinol. 2007 May 1;151(3):308-17. Epub 2007 Jan 25. PubMed PMID: 17350013.</span><br />
<span style="/font-family:Arial;font-size:14px;/">4: Bay&eacute;s M, Rabasseda X, Prous JR. Gateways to clinical trials. Methods Find Exp Clin Pharmacol. 2004 Oct;26(8):639-63. PubMed PMID: 15605126.</span><br />
<span style="/font-family:Arial;font-size:14px;/">5: Yanagida K, Yaekura K, Arima T, Yada T. Glucose-insensitivity induced by Ca(2+) toxicity in islet beta-cells and its prevention by PACAP. Peptides. 2002 Jan;23(1):135-42. PubMed PMID: 11814628.</span><br />
<span style="/font-family:Arial;font-size:14px;/">6: Yada T, Nakata M, Shioda S. Insulinotropin PACAP potentiates insulin action. Stimulation of glucose uptake in 3T3-LI adipocytes. Ann N Y Acad Sci. 2000;921:473-7. PubMed PMID: 11193879.</span><br />
<span style="/font-family:Arial;font-size:14px;/">7: Nakata M, Shioda S, Oka Y, Maruyama I, Yada T. Insulinotropin PACAP potentiates insulin-stimulated glucose uptake in 3T3 L1 cells. Peptides. 1999;20(8):943-8. PubMed PMID: 10503772.</span><br />
<span style="/font-family:Arial;font-size:14px;/">8: Plisetskaya EM, Mommsen TP. Glucagon and glucagon-like peptides in fishes. Int Rev Cytol. 1996;168:187-257. Review. PubMed PMID: 8843650.</span><br />
<span style="/font-family:Arial;font-size:14px;/">9: Kim Y, Haren AM. The application of crystal soaking technique to study the effect of zinc and cresol on insulinotropin crystals grown from a saline solution. Pharm Res. 1995 Nov;12(11):1664-70. PubMed PMID: 8592667.</span><br />
<span style="/font-family:Arial;font-size:14px;/">10: Qi H, Heller DL. Stability and stabilization of insulinotropin in a dextran formulation. PDA J Pharm Sci Technol. 1995 Nov-Dec;49(6):289-93. PubMed PMID: 8581460.</span><br />
<span style="/font-family:Arial;font-size:14px;/">11: Kim Y, Rose CA. Precipitation of insulinotropin in the presence of protamine: effect of phenol and zinc on the isophane ratio and the insulinotropin concentration in the supernatant. Pharm Res. 1995 Sep;12(9):1284-8. PubMed PMID: 8570522.</span><br />
<span style="/font-family:Arial;font-size:14px;/">12: Kim Y, Rose CA, Liu Y, Ozaki Y, Datta G, Tu AT. FT-IR and near-infrared FT-Raman studies of the secondary structure of insulinotropin in the solid state: alpha-helix to beta-sheet conversion induced by phenol and/or by high shear force. J Pharm Sci. 1994 Aug;83(8):1175-80. PubMed PMID: 7983604.</span><br />
<span style="/font-family:Arial;font-size:14px;/">13: Brophy RT, Lambert WJ. The adsorption of insulinotropin to polymeric sterilizing filters. J Pharm Sci Technol. 1994 Mar-Apr;48(2):92-4. PubMed PMID: 8032801.</span><br />
<span style="/font-family:Arial;font-size:14px;/">14: Koyama N, Kuriyama M, Amano N, Nishimura O. A novel procedure for the preparation of biologically active recombinant peptides using a cyanylation reaction. J Biotechnol. 1994 Feb 28;32(3):273-81. PubMed PMID: 7764719.</span><br />
<span style="/font-family:Arial;font-size:14px;/">15: Mommsen TP, Plisetskaya EM. Metabolic and endocrine functions of glucagon-like peptides – evolutionary and biochemical perspectives. Fish Physiol Biochem. 1993 Jul;11(1-6):429-38. doi: 10.1007/BF00004593. PubMed PMID: 24202503.</span><br />
<span style="/font-family:Arial;font-size:14px;/">16: Mentlein R, Gallwitz B, Schmidt WE. Dipeptidyl-peptidase IV hydrolyses gastric inhibitory polypeptide, glucagon-like peptide-1(7-36)amide, peptide histidine methionine and is responsible for their degradation in human serum. Eur J Biochem. 1993 Jun 15;214(3):829-35. PubMed PMID: 8100523.</span><br />
<span style="/font-family:Arial;font-size:14px;/">17: Mojsov S, Weir GC, Habener JF. Insulinotropin: glucagon-like peptide I (7-37) co-encoded in the glucagon gene is a potent stimulator of insulin release in the perfused rat pancreas. J Clin Invest. 1987 Feb;79(2):616-9. PubMed PMID: 3543057; PubMed Central PMCID: PMC424143.&nbsp;</span>

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