For research use only. Not for therapeutic Use.
Gilmelisib (Cat No.:I044407) is a potent, selective inhibitor of phosphoinositide 3-kinase delta (PI3K-δ) and gamma (PI3K-γ), two isoforms critical for immune cell signaling. With nanomolar potency, Gilmelisib blocks activation and proliferation of B and T lymphocytes, making it a valuable compound in inflammatory and autoimmune disease research. It also shows promise in hematological malignancies by disrupting survival signaling in malignant leukocytes. Gilmelisib is commonly used to explore PI3K pathway modulation in models of lymphoma, leukemia, and other immune-driven pathologies.
| CAS Number | 1845777-61-8 |
| Synonyms | 2-chloro-N-[5-[3-[2-(dimethylamino)ethoxy]-4-oxopyrido[1,2-a]pyrimidin-7-yl]-2-methoxypyridin-3-yl]-4-fluorobenzenesulfonamide |
| Molecular Formula | C24H23ClFN5O5S |
| Purity | ≥95% |
| IUPAC Name | 2-chloro-N-[5-[3-[2-(dimethylamino)ethoxy]-4-oxopyrido[1,2-a]pyrimidin-7-yl]-2-methoxypyridin-3-yl]-4-fluorobenzenesulfonamide |
| InChI | InChI=1S/C24H23ClFN5O5S/c1-30(2)8-9-36-20-13-27-22-7-4-15(14-31(22)24(20)32)16-10-19(23(35-3)28-12-16)29-37(33,34)21-6-5-17(26)11-18(21)25/h4-7,10-14,29H,8-9H2,1-3H3 |
| InChIKey | BXKBZQAZYOZHJY-UHFFFAOYSA-N |
| SMILES | CN(C)CCOC1=CN=C2C=CC(=CN2C1=O)C3=CC(=C(N=C3)OC)NS(=O)(=O)C4=C(C=C(C=C4)F)Cl |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
