Gestonorone

• CAT Number: R019895
• CAS Number: 2137-18-0
• Molecular Formula: C20H28O3
• Molecular Weight: 316.441
• Purity: ≥95%
• Synonyms: 17-Hydroxy-19-norpregn-4-ene-3,20-dione; 17α-Hydroxy-19-norpregn-4-ene-3,20-dione; 17α-Hydroxy-19-norprogesterone; Gestonorone; TX 045
• Solubility: Chloroform (Slightly), Methanol (Slightly)
• Storage: Refrigerator
• IUPAC Name: (8R,9S,10R,13S,14S,17R)-17-acetyl-17-hydroxy-13-methyl-1,2,6,7,8,9,10,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-3-one
• InChI: InChI=1S/C20H28O3/c1-12(21)20(23)10-8-18-17-5-3-13-11-14(22)4-6-15(13)16(17)7-9-19(18,20)2/h11,15-18,23H,3-10H2,1-2H3/t15-,16+,17+,18-,19-,20-/m0/s1
• InChIKey: GTFUITFQDGVJSK-XGXHKTLJSA-N
• SMILES: CC(=O)C1(CCC2C1(CCC3C2CCC4=CC(=O)CCC34)C)O

Gestronol (BAN), also known as gestonorone, as well as 17α-hydroxy-19-norprogesterone or 17α-hydroxy-19-norpregn-4-ene-3,20-dione, is a steroidal progestin of the 19-norprogesterone and 17α-hydroxyprogesterone groups that was never marketed. The C17α caproate ester of gestronol, gestonorone caproate (gestronol hexanoate), in contrast, has been marketed.

Reference

1: Lopatkin N, Darenkow A, Sahmatow J, Tankó A, Ignaschin N, Warentsow G.
[Gestonorone therapy of prostatic adenoma]. Acta Chir Acad Sci Hung.
1980;21(4):271-8. German. PubMed PMID: 6175122.

2: Luciani L, Frizzi V. [On a new synthetic gestagen, gestonorone. Its use in the
treatment of prostatic hypertrophy and histological control of its effects on the
male gonad]. Minerva Urol. 1969 Nov-Dec;21(6):203-13. Italian. PubMed PMID:
4104300.