For research use only. Not for therapeutic Use.
Gemnelatinib (Cat No.: I028000) is a potent, selective inhibitor of fibroblast growth factor receptors (FGFR1, FGFR2, and FGFR3), developed for the treatment of cancers driven by FGFR genetic alterations, such as fusions, mutations, or amplifications. By targeting FGFR signaling, gemnelatinib disrupts pathways involved in tumor cell proliferation, survival, and angiogenesis. It has shown promising antitumor activity in preclinical and early clinical studies, particularly in cholangiocarcinoma and urothelial carcinoma. Gemnelatinib is being evaluated in clinical trials as a precision oncology therapy.
| CAS Number | 2225123-30-6 |
| Synonyms | 2-[5-fluoro-1-[(1R)-1-[3-[5-[(1-methylpiperidin-4-yl)methoxy]pyrimidin-2-yl]phenyl]ethyl]-6-oxopyridin-3-yl]pyridine-4-carbonitrile |
| Molecular Formula | C30H29FN6O2 |
| Purity | ≥95% |
| InChI | InChI=1S/C30H29FN6O2/c1-20(37-18-25(14-27(31)30(37)38)28-12-22(15-32)6-9-33-28)23-4-3-5-24(13-23)29-34-16-26(17-35-29)39-19-21-7-10-36(2)11-8-21/h3-6,9,12-14,16-18,20-21H,7-8,10-11,19H2,1-2H3/t20-/m1/s1 |
| InChIKey | UDDRTVZAZBIBBN-HXUWFJFHSA-N |
| SMILES | CC(C1=CC=CC(=C1)C2=NC=C(C=N2)OCC3CCN(CC3)C)N4C=C(C=C(C4=O)F)C5=NC=CC(=C5)C#N |
| Reference | [1]. WO2018077227 |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
