Gemfibrozil

• CAT Number: A001175
• CAS Number: 25812-30-0
• Molecular Formula: C15H22O3
• Molecular Weight: 250.3
• Purity: ≥95%
• Target: PPAR
• Solubility: >10.2mg/mL in DMSO
• Storage: 3 years -20C powder
• InChIKey: HEMJJKBWTPKOJG-UHFFFAOYSA-N

Gemfibrozil is a peroxisome proliferator receptor alpha agonist. The mechanism of action of gemfibrozil is as a Peroxisome Proliferator-activated Receptor alpha Agonist. The chemical classification of gemfibrozil is PPAR alpha. Gemfibrozil is a lipid-regulating agent that lowers elevated serum lipids primarily by decreasing serum triglycerides with a variable reduction in total cholesterol.

Reference

1:Quantitative Analysis of Complex Drug-Drug Interactions Between Repaglinide and Cyclosporin A/Gemfibrozil Using Physiologically Based Pharmacokinetic Models With In Vitro Transporter/Enzyme Inhibition Data. Kim SJ, Toshimoto K, Yao Y, Yoshikado T, Sugiyama Y.J Pharm Sci. 2017 May 4. pii: S0022-3549(17)30333-7. doi: 10.1016/j.xphs.2017.04.063. [Epub ahead of print] PMID: 28479356 2:Peroxisome Proliferator-Activated Receptor α Activation Suppresses Cytochrome P450 Induction Potential in Mice Treated with Gemfibrozil. Shi C, Min L, Yang J, Dai M, Song D, Hua H, Xu G, Gonzalez FJ, Liu A.Basic Clin Pharmacol Toxicol. 2017 Apr 4. doi: 10.1111/bcpt.12794. [Epub ahead of print] PMID: 28374976 3:Transport behavior of the pharmaceutical compounds carbamazepine, sulfamethoxazole, gemfibrozil, ibuprofen, and naproxen, and the lifestyle drug caffeine, in saturated laboratory columns. Hebig KH, Groza LG, Sabourin MJ, Scheytt TJ, Ptacek CJ.Sci Total Environ. 2017 Jul 15;590-591:708-719. doi: 10.1016/j.scitotenv.2017.03.031. Epub 2017 Mar 8. PMID: 28284639 4:Gemfibrozil, food and drug administration-approved lipid-lowering drug, increases longevity in mouse model of late infantile neuronal ceroid lipofuscinosis. Ghosh A, Rangasamy SB, Modi KK, Pahan K.J Neurochem. 2017 May;141(3):423-435. doi: 10.1111/jnc.13987. Epub 2017 Apr 3. PMID: 28199020 5:Modelling the photochemical attenuation pathways of the fibrate drug gemfibrozil in surface waters. Fabbri D, Maurino V, Minella M, Minero C, Vione D.Chemosphere. 2017 Mar;170:124-133. doi: 10.1016/j.chemosphere.2016.11.135. Epub 2016 Dec 14. PMID: 27987461 6:Association of Serum Triglyceride Level and Gemfibrozil Consumption With Periodontal Status. Sayar F, Akhondi N, Fallah S, Moalemnia AA, Cheraghi A.J Periodontol. 2017 May;88(5):457-463. doi: 10.1902/jop.2016.160366. Epub 2016 Dec 13. PMID: 27958766 7:PPARα-dependent increase of mouse urine output by gemfibrozil and fenofibrate. Song D, Luo M, Dai M, Bu S, Wang W, Zhang B, Gonzalez FJ, Liu A.Can J Physiol Pharmacol. 2017 Feb;95(2):199-205. doi: 10.1139/cjpp-2016-0140. Epub 2016 Sep 6. PMID: 27918198 8:Effect of the lipid regulator Gemfibrozil in the Cladocera Daphnia magna at different temperatures. Salesa B, Ferrando MD, Villarroel MJ, Sancho E.J Environ Sci Health A Tox Hazard Subst Environ Eng. 2017 Feb 23;52(3):228-234. doi: 10.1080/10934529.2016.1246937. Epub 2016 Nov 11. PMID: 27835067 9:Role of gemfibrozil as an inhibitor of CYP2C8 and membrane transporters. Tornio A, Neuvonen PJ, Niemi M, Backman JT.Expert Opin Drug Metab Toxicol. 2017 Jan;13(1):83-95. Epub 2016 Aug 31. Review. PMID: 27548563 10:Evaluation of gemfibrozil effects on a marine fish (Sparus aurata) combining gene expression with conventional endocrine and biochemical endpoints. Teles M, Fierro-Castro C, Na-Phatthalung P, Tvarijonaviciute A, Soares AM, Tort L, Oliveira M.J Hazard Mater. 2016 Nov 15;318:600-7. doi: 10.1016/j.jhazmat.2016.07.044. Epub 2016 Jul 21. PMID: 27474849