Gemcitabine - CAS 95058-81-4
Gemcitabine, a nucleic acid synthesis inhibitor, is a very potent and specific deoxycytidine analogue, used as chemotherapy.
Gemcitabine results in 50% inhibition of growth in the CCRF-CEM human leukemia cell culture assay with IC50 of 1 ng/ml. Gemcitabine combined with deoxycytidine provides about a 1000-fold decrease in biological activity.
Gemcitabine combined with C225 results in growth inhibition, tumor regression, and abrogation of metastasis in L3.6pl tumors established in the pancreas of nude mice. Gemcitabine treatment alone reduces median tumor volume from 538 to 152 mm
Catalog Number: A000739
CAS Number: 95058-81-4
PubChem Substance ID:355040255
Molecular Formula: C9H11F2N3O4
Molecular Weight:263.201
Purity: ≥95%
* For research use only. Not for human or veterinary use.
Synonym
| Synonyms | LY-188011, NSC 613327 |
|---|
Property
| Molecular Formula: | C9H11F2N3O4 |
|---|---|
| Molecular Weight | 263.201 |
| Target: | DNA Synthesis |
| Solubility | Soluble in DMSO > 10 mM |
| Purity | ≥95% |
| Storage | 3 years -20C powder |
Computed Descriptor
| IUPAC Name | 4-amino-1-[(2R,4R,5R)-3,3-difluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one |
|---|---|
| InChI | InChI=1S/C9H11F2N3O4/c10-9(11)6(16)4(3-15)18-7(9)14-2-1-5(12)13-8(14)17/h1-2,4,6-7,15-16H,3H2,(H2,12,13,17)/t4-,6-,7-/m1/s1 |
| InChIKey | SDUQYLNIPVEERB-QPPQHZFASA-N |
| SMILES | C1=CN(C(=O)N=C1N)C2C(C(C(O2)CO)O)(F)F |