Gemcitabine - CAS 95058-81-4

Gemcitabine, a nucleic acid synthesis inhibitor, is a very potent and specific deoxycytidine analogue, used as chemotherapy.
Gemcitabine results in 50% inhibition of growth in the CCRF-CEM human leukemia cell culture assay with IC50 of 1 ng/ml. Gemcitabine combined with deoxycytidine provides about a 1000-fold decrease in biological activity.
Gemcitabine combined with C225 results in growth inhibition, tumor regression, and abrogation of metastasis in L3.6pl tumors established in the pancreas of nude mice. Gemcitabine treatment alone reduces median tumor volume from 538 to 152 mm

Catalog Number: A000739

CAS Number: 95058-81-4

PubChem Substance ID:355040255

Molecular Formula: C9H11F2N3O4

Molecular Weight:263.201

Purity: ≥95%

* For research use only. Not for human or veterinary use.


SynonymsLY-188011, NSC 613327


Molecular Formula: C9H11F2N3O4
Molecular Weight263.201
Target:DNA Synthesis
SolubilitySoluble in DMSO > 10 mM
Storage3 years -20C powder

Computed Descriptor

IUPAC Name4-amino-1-[(2R,4R,5R)-3,3-difluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one