Geldanamycin-FITC

• CAT Number: I045872
• CAS Number: 2969156-01-0
• Molecular Formula: C55H63N5O13S
• Molecular Weight: 1034.18
• Purity: ≥95%
• Synonyms: 5-[6-[[(4E,6Z,8S,9S,10E,12S,13R,14S,16R)-9-carbamoyloxy-13-hydroxy-8,14-dimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-2-azabicyclo[16.3.1]docosa-1(21),4,6,10,18-pentaen-19-yl]amino]hexylcarbamothioylamino]-2-(3-hydroxy-6-oxoxanthen-9-yl)benzoic acid
• InChI: InChI=1S/C55H63N5O13S/c1-29-22-40-48(42(63)28-41(50(40)65)60-52(66)30(2)12-11-13-43(70-5)51(73-54(56)69)32(4)24-31(3)49(64)46(23-29)71-6)57-20-9-7-8-10-21-58-55(74)59-33-14-17-36(39(25-33)53(67)68)47-37-18-15-34(61)26-44(37)72-45-27-35(62)16-19-38(45)47/h11-19,24-29,31,43,46,49,51,57,61,64H,7-10,20-23H2,1-6H3,(H2,56,69)(H,60,66)(H,67,68)(H2,58,59,74)/b13-11-,30-12+,32-24+/t29-,31+,43+,46+,49-,51+/m1/s1
• InChIKey: NLCWMGUTUFWVHY-CPMGOHQRSA-N
• SMILES: C[C@H]1C[C@@H]([C@@H]([C@H](/C=C(/[C@@H]([C@H](/C=C\C=C(\C(=O)NC2=CC(=O)C(=C(C1)C2=O)NCCCCCCNC(=S)NC3=CC(=C(C=C3)C4=C5C=CC(=O)C=C5OC6=C4C=CC(=C6)O)C(=O)O)/C)OC)OC(=O)N)\C)C)O)OC

Geldanamycin-FITC（Cat No.:I045872）is a fluorescent conjugate combining geldanamycin, a potent Hsp90 inhibitor, with fluorescein isothiocyanate (FITC) for imaging and assay applications. Geldanamycin binds to the N-terminal ATP-binding pocket of Hsp90, disrupting chaperone function and leading to the degradation of client proteins involved in cancer progression. The FITC label provides strong green fluorescence, enabling visualization, detection, and quantification in live-cell imaging, flow cytometry, and fluorescence-based binding studies. This probe is widely used in chemical biology and cancer research to study Hsp90 interactions, inhibitor dynamics, and cellular localization.