Gefitinib-based PROTAC 3 - CAS 2230821-27-7

Gefitinib-based PROTAC 3 (CAT: I019173) is a cutting-edge molecular tool designed to harness the principles of proteolysis-targeting chimeras (PROTACs) for targeted protein degradation. By ingeniously combining an EGFR binding moiety with a Von Hippel-Lindau (VHL) ligand through a specialized linker, this innovative compound demonstrates its remarkable ability to induce degradation of the epidermal growth factor receptor (EGFR). In HCC827 cells harboring the exon 19 deletion mutation, Gefitinib-based PROTAC 3 achieves a compelling DC50 of 11.7 nM, while in H3255 cells carrying the L858R mutation, it exhibits an impressive DC50 of 22.3 nM.

Catalog Number: I019173

CAS Number: 2230821-27-7

Molecular Formula: C₄₇H₅₇ClFN₇O₈S

Molecular Weight:934.51

Purity: ≥95%

* For research use only. Not for human or veterinary use.


Molecular Formula: C₄₇H₅₇ClFN₇O₈S
Molecular Weight934.51