GDC-6599

• CAT Number: I040764
• CAS Number: 2376824-99-4
• Molecular Formula: C20H19ClN6O3
• Molecular Weight: 426.86
• Purity: ≥95%
• Synonyms: 1-[[3-[(3R,5R)-5-(4-chlorophenyl)oxolan-3-yl]-1,2,4-oxadiazol-5-yl]methyl]-2,7-dimethylpurin-6-one
• InChI: InChI=1S/C20H19ClN6O3/c1-11-23-19-17(26(2)10-22-19)20(28)27(11)8-16-24-18(25-30-16)13-7-15(29-9-13)12-3-5-14(21)6-4-12/h3-6,10,13,15H,7-9H2,1-2H3/t13-,15+/m0/s1
• InChIKey: FIBJEOLUMVIRIT-DZGCQCFKSA-N
• SMILES: CC1=NC2=C(C(=O)N1CC3=NC(=NO3)C4CC(OC4)C5=CC=C(C=C5)Cl)N(C=N2)C

GDC-6599 (CAT: I040764) is an orally active inhibitor of transient receptor potential ankyrin 1 (TRPA1), a non-selective cation channel involved in the detection of noxious stimuli, oxidative stress, and inflammatory signaling. By selectively blocking TRPA1 activity, GDC-6599 reduces sensory neuron activation, making it a valuable tool for studying TRPA1-mediated diseases, particularly various types of pain, including inflammatory, neuropathic, and chemical-induced pain. Its oral bioavailability allows for convenient in vivo use in preclinical pain models. GDC-6599 holds potential in the development of novel analgesics targeting TRPA1 and in advancing our understanding of sensory and inflammatory pathophysiology.