For research use only. Not for therapeutic Use.
GDC-0310（Cat No.:I027989）is a potent, selective small-molecule antagonist of the chemokine receptor CCR2, which plays a critical role in monocyte recruitment and inflammatory signaling. By blocking CCR2, GDC-0310 inhibits the binding of its ligand CCL2 (MCP-1), reducing the migration of inflammatory monocytes and macrophages to sites of tissue damage or tumor growth. It has been investigated in preclinical and clinical studies for the treatment of inflammatory diseases and cancer, particularly in modulating the tumor microenvironment. GDC-0310 supports research into immune cell trafficking and targeted anti-inflammatory or anticancer therapies.
| CAS Number | 1788063-52-4 |
| Synonyms | 5-cyclopropyl-4-[[1-[(1S)-1-(3,5-dichlorophenyl)ethyl]piperidin-4-yl]methoxy]-2-fluoro-N-methylsulfonylbenzamide |
| Molecular Formula | C25H29Cl2FN2O4S |
| Purity | ≥95% |
| IUPAC Name | 5-cyclopropyl-4-[[1-[(1S)-1-(3,5-dichlorophenyl)ethyl]piperidin-4-yl]methoxy]-2-fluoro-N-methylsulfonylbenzamide |
| InChI | InChI=1S/C25H29Cl2FN2O4S/c1-15(18-9-19(26)11-20(27)10-18)30-7-5-16(6-8-30)14-34-24-13-23(28)22(12-21(24)17-3-4-17)25(31)29-35(2,32)33/h9-13,15-17H,3-8,14H2,1-2H3,(H,29,31)/t15-/m0/s1 |
| InChIKey | SXOAHIZWCZOILH-HNNXBMFYSA-N |
| SMILES | C[C@@H](C1=CC(=CC(=C1)Cl)Cl)N2CCC(CC2)COC3=CC(=C(C=C3C4CC4)C(=O)NS(=O)(=O)C)F |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
