GCN2-IN-6

• CAT Number: I017736
• CAS Number: 2183470-09-7
• Molecular Formula: C19H12Cl2F2N4O3S
• Molecular Weight: 485.29
• Purity: ≥95%
• Synonyms: N-[3-[2-(2-aminopyrimidin-5-yl)ethynyl]-2,4-difluorophenyl]-2,5-dichloro-3-(hydroxymethyl)benzenesulfonamide
• InChI: InChI=1S/C19H12Cl2F2N4O3S/c20-12-5-11(9-28)17(21)16(6-12)31(29,30)27-15-4-3-14(22)13(18(15)23)2-1-10-7-25-19(24)26-8-10/h3-8,27-28H,9H2,(H2,24,25,26)
• InChIKey: VJXAWOQPYMAEFQ-UHFFFAOYSA-N
• SMILES: C1=CC(=C(C(=C1NS(=O)(=O)C2=CC(=CC(=C2Cl)CO)Cl)F)C#CC3=CN=C(N=C3)N)F

GCN2-IN-6（Cat No.:I017736）is a selective inhibitor of general control nonderepressible 2 (GCN2), a serine/threonine-protein kinase that senses amino acid deprivation and activates the integrated stress response (ISR). By blocking GCN2 activity, this compound helps dissect pathways regulating protein synthesis, cellular metabolism, and stress adaptation. GCN2-IN-6 is valuable for studying cancer, neurodegeneration, and metabolic disorders where ISR signaling is dysregulated. Its ability to modulate stress-related translational control makes it an essential research tool for exploring therapeutic strategies targeting nutrient sensing and stress response mechanisms.