For research use only. Not for therapeutic Use.
GB111-NH2 hydrochloride(CAT: I040225) is a potent and selective cysteine cathepsin inhibitor, primarily targeting cathepsins B, L, and S. These proteases are critically involved in tumor progression, metastasis, and immune modulation, making GB111-NH2 a valuable tool for cancer research. By irreversibly binding to the active site cysteine of these enzymes, it allows for precise investigation of cathepsin function in pathological and physiological contexts. GB111-NH2 is widely used in imaging studies and protease profiling due to its structural compatibility with fluorescent tagging. It supports mechanistic studies of protease-driven tumor microenvironment remodeling and immunological alterations in oncology-focused research applications.
| Synonyms | [(3S)-7-amino-2-oxo-3-[[(2S)-3-phenyl-2-(phenylmethoxycarbonylamino)propanoyl]amino]heptyl] 2,6-dimethylbenzoate;hydrochloride |
| Molecular Formula | C33H40ClN3O6 |
| Purity | ≥95% |
| IUPAC Name | [(3S)-7-amino-2-oxo-3-[[(2S)-3-phenyl-2-(phenylmethoxycarbonylamino)propanoyl]amino]heptyl] 2,6-dimethylbenzoate;hydrochloride |
| InChI | InChI=1S/C33H39N3O6.ClH/c1-23-12-11-13-24(2)30(23)32(39)41-22-29(37)27(18-9-10-19-34)35-31(38)28(20-25-14-5-3-6-15-25)36-33(40)42-21-26-16-7-4-8-17-26;/h3-8,11-17,27-28H,9-10,18-22,34H2,1-2H3,(H,35,38)(H,36,40);1H/t27-,28-;/m0./s1 |
| InChIKey | LEQYHRMMCXGQOI-DHBRAOIWSA-N |
| SMILES | CC1=C(C(=CC=C1)C)C(=O)OCC(=O)C(CCCCN)NC(=O)C(CC2=CC=CC=C2)NC(=O)OCC3=CC=CC=C3.Cl |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
