For research use only. Not for therapeutic Use.
GATA4-NKX2-5-IN-1（Cat No.:I018296）is a small-molecule inhibitor that disrupts the protein–protein interaction between transcription factors GATA4 and NKX2-5, both of which are critical for cardiac development and function. By selectively blocking this interaction, the compound interferes with downstream gene transcription programs driving cardiac hypertrophy and remodeling. GATA4-NKX2-5-IN-1 is used in research to study molecular mechanisms underlying heart disease and to evaluate potential therapeutic strategies for pathological cardiac growth. It provides a valuable tool for probing transcriptional regulation in cardiovascular biology and disease models.
| CAS Number | 544681-96-1 |
| Synonyms | N-[4-(diethylamino)phenyl]-5-methyl-3-phenyl-1,2-oxazole-4-carboxamide |
| Molecular Formula | C21H23N3O2 |
| Purity | ≥95% |
| IUPAC Name | N-[4-(diethylamino)phenyl]-5-methyl-3-phenyl-1,2-oxazole-4-carboxamide |
| InChI | InChI=1S/C21H23N3O2/c1-4-24(5-2)18-13-11-17(12-14-18)22-21(25)19-15(3)26-23-20(19)16-9-7-6-8-10-16/h6-14H,4-5H2,1-3H3,(H,22,25) |
| InChIKey | UDDOZWWBHVIGDS-UHFFFAOYSA-N |
| SMILES | CCN(CC)C1=CC=C(C=C1)NC(=O)C2=C(ON=C2C3=CC=CC=C3)C |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
