Gambogenic acid

• CAT Number: I017925
• CAS Number: 173932-75-7
• Molecular Formula: C38H46O8
• Molecular Weight: 630.77
• Purity: ≥95%
• Synonyms: (Z)-4-[(1S,2S,13S,15R)-7-[(2E)-3,7-dimethylocta-2,6-dienyl]-6,8-dihydroxy-17,17-dimethyl-5-(3-methylbut-2-enyl)-10,14-dioxo-3,16-dioxapentacyclo[11.4.1.02,11.02,15.04,9]octadeca-4,6,8,11-tetraen-15-yl]-2-methylbut-2-enoic acid
• InChI: InChI=1S/C38H46O8/c1-20(2)10-9-11-22(5)13-15-25-30(39)26(14-12-21(3)4)33-29(31(25)40)32(41)27-18-24-19-28-36(7,8)46-37(34(24)42,38(27,28)45-33)17-16-23(6)35(43)44/h10,12-13,16,18,24,28,39-40H,9,11,14-15,17,19H2,1-8H3,(H,43,44)/b22-13+,23-16-/t24-,28+,37+,38-/m1/s1
• InChIKey: RCWNBHCZYXWDOV-VSFMGBBVSA-N
• SMILES: CC(=CCC/C(=C/CC1=C(C(=C2C(=C1O)C(=O)C3=C[C@@H]4C[C@@H]5[C@@]3(O2)[C@](C4=O)(OC5(C)C)C/C=C(/C)\C(=O)O)CC=C(C)C)O)/C)C

Gambogenic acid（Cat No.:I017925）is a bioactive xanthonoid compound derived from the resin of Garcinia hanburyi (gamboge). It demonstrates strong anticancer, anti-inflammatory, and pro-apoptotic activities. Mechanistically, gambogenic acid induces apoptosis and autophagy by modulating pathways such as NF-κB, MAPK, and PI3K/Akt, leading to suppression of tumor growth and metastasis. It also exhibits anti-inflammatory effects by reducing cytokine production and oxidative stress. Preclinical studies highlight its potential in treating various cancers and inflammatory conditions. As a natural product, gambogenic acid serves as a valuable lead for drug discovery research.