For research use only. Not for therapeutic Use.
GAK Inhibitor 49 hydrochloride（Cat No.:I044361）is a selective small-molecule inhibitor targeting cyclin G-associated kinase (GAK), a serine/threonine kinase involved in clathrin-mediated endocytosis, cell cycle regulation, and receptor trafficking. By inhibiting GAK activity, this compound disrupts intracellular transport pathways and has shown potential in sensitizing cancer cells to chemotherapeutic agents and blocking viral entry, including that of SARS-CoV-2. The hydrochloride salt form enhances its solubility and stability for in vitro and in vivo studies. GAK Inhibitor 49 hydrochloride is a valuable research tool for exploring GAK function in cellular signaling, virology, and oncology.
| CAS Number | 2930378-91-7 |
| Synonyms | 6,7-dimethoxy-N-(3,4,5-trimethoxyphenyl)quinolin-4-amine;hydrochloride |
| Molecular Formula | C20H23ClN2O5 |
| Purity | ≥95% |
| IUPAC Name | 6,7-dimethoxy-N-(3,4,5-trimethoxyphenyl)quinolin-4-amine;hydrochloride |
| InChI | InChI=1S/C20H22N2O5.ClH/c1-23-16-10-13-14(6-7-21-15(13)11-17(16)24-2)22-12-8-18(25-3)20(27-5)19(9-12)26-4;/h6-11H,1-5H3,(H,21,22);1H |
| InChIKey | LOOMZTXOCDWFDB-UHFFFAOYSA-N |
| SMILES | COC1=CC(=CC(=C1OC)OC)NC2=C3C=C(C(=CC3=NC=C2)OC)OC.Cl |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
