Gadolinium chloride

• CAT Number: R042207
• CAS Number: 10138-52-0
• Molecular Formula: Cl3Gd
• Molecular Weight: 263.61
• Purity: ≥95%
• Synonyms: trichlorogadolinium
• InChI: InChI=1S/3ClH.Gd/h3*1H;/q;;;+3/p-3
• InChIKey: MEANOSLIBWSCIT-UHFFFAOYSA-K
• SMILES: Cl[Gd](Cl)Cl

Gadolinium chloride is a specific calcium-sensing receptor (CaSR) agonist. Gadolinium chloride can be used for the research of cardiovascular disease[1].
Gadolinium chloride (30 μM; 15 minutes; H9c2 cells) results in increased Bax expression and caspase-3 activation, and decreased Bcl-2 expression in CsA-induced cells[1].
In vitro, GdCl3, a CaSR agonist, has been shown to promote the apoptosis of myocardial cells, which increases ERK1/2 phosphorylation and activates caspase-3[1].

Reference

[1]. Li X, et al. Calcium Oxalate Induces Renal Injury through Calcium-Sensing Receptor. Oxid Med Cell Longev. 2016;2016:5203801.
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