G244-LM

• CAT Number: R067042
• CAS Number: 1563007-08-8
• Molecular Formula: C18H22N4O3S2
• Molecular Weight: 406.52
• Purity: ≥95%
• Synonyms: 2-[4-(2-methylsulfonylphenyl)piperazin-1-yl]-3,5,7,8-tetrahydrothiopyrano[4,3-d]pyrimidin-4-one
• InChI: InChI=1S/C18H22N4O3S2/c1-27(24,25)16-5-3-2-4-15(16)21-7-9-22(10-8-21)18-19-14-6-11-26-12-13(14)17(23)20-18/h2-5H,6-12H2,1H3,(H,19,20,23)
• InChIKey: JSQPAEVPPSCQMV-UHFFFAOYSA-N
• SMILES: CS(=O)(=O)C1=CC=CC=C1N2CCN(CC2)C3=NC4=C(CSCC4)C(=O)N3

G244-LM (Cat No.: R067042) is a selective small-molecule inhibitor of survivin, a member of the inhibitor of apoptosis (IAP) protein family that plays critical roles in cell cycle regulation and apoptosis resistance. By targeting survivin, G244-LM disrupts mitotic progression and sensitizes cancer cells to apoptotic stimuli. It has been explored in preclinical models as a potential anticancer agent, demonstrating the ability to reduce tumor growth and enhance the effects of chemotherapeutics. G244-LM is a valuable tool for studying apoptosis, mitosis, and cancer biology.

Reference

[1]. Lau T, et al. A novel tankyrase small-molecule inhibitor suppresses APC mutation-driven colorectal tumor growth. Cancer Res. 2013 May 15;73(10):3132-44.
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