For research use only. Not for therapeutic Use.
G140 (Cat No.: I045352) is a next-generation HIV-1 integrase inhibitor designed to block the integration of viral DNA into the host genome, a critical step in the HIV replication cycle. It demonstrates potent antiviral activity by binding to the integrase enzyme and disrupting its function. G140 is part of a class of long-acting antiretroviral agents under investigation for improved adherence and resistance profiles. It holds promise for enhancing HIV treatment strategies, particularly in combination therapies aiming for sustained viral suppression and better patient compliance.
| CAS Number | 2369751-07-3 |
| Synonyms | 1-[6,7-dichloro-9-(1-methylpyrazol-3-yl)-1,3,4,5-tetrahydropyrido[4,3-b]indol-2-yl]-2-hydroxyethanone |
| Molecular Formula | C17H16Cl2N4O2 |
| Purity | ≥95% |
| InChI | InChI=1S/C17H16Cl2N4O2/c1-22-4-2-13(21-22)9-6-11(18)16(19)17-15(9)10-7-23(14(25)8-24)5-3-12(10)20-17/h2,4,6,20,24H,3,5,7-8H2,1H3 |
| InChIKey | NVPFAXHXXODQRO-UHFFFAOYSA-N |
| SMILES | CN1C=CC(=N1)C2=CC(=C(C3=C2C4=C(N3)CCN(C4)C(=O)CO)Cl)Cl |
| Reference | [1]. Lama L, et, al. Development of human cGAS-specific small-molecule inhibitors for repression of dsDNA-triggered interferon expression. Nat Commun. 2019 May 21; 10(1): 2261. |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
