For research use only. Not for therapeutic Use.
Fulvestrant-d3（Cat No.:R006314）is a deuterated analog of fulvestrant, a selective estrogen receptor degrader (SERD) used in the treatment of hormone receptor-positive breast cancer. In Fulvestrant-d3, three hydrogen atoms are replaced with deuterium, a stable isotope of hydrogen, enhancing its utility in pharmacokinetic studies and mass spectrometry-based bioanalytical assays. It retains the biological activity of the parent compound, binding to estrogen receptors and promoting their degradation to inhibit estrogen signaling. Fulvestrant-d3 is primarily used as an internal standard in drug metabolism, distribution studies, and analytical method development for fulvestrant quantification.
| Synonyms | (7R,8R,9S,13S,14S,17S)-16,16,17-trideuterio-13-methyl-7-[9-(4,4,5,5,5-pentafluoropentylsulfinyl)nonyl]-6,7,8,9,11,12,14,15-octahydrocyclopenta[a]phenanthrene-3,17-diol |
| Molecular Formula | C32H44D3F5O3S |
| Purity | ≥95% |
| IUPAC Name | (7R,8R,9S,13S,14S,17S)-16,16,17-trideuterio-13-methyl-7-[9-(4,4,5,5,5-pentafluoropentylsulfinyl)nonyl]-6,7,8,9,11,12,14,15-octahydrocyclopenta[a]phenanthrene-3,17-diol |
| InChI | InChI=1S/C32H47F5O3S/c1-30-17-15-26-25-12-11-24(38)21-23(25)20-22(29(26)27(30)13-14-28(30)39)10-7-5-3-2-4-6-8-18-41(40)19-9-16-31(33,34)32(35,36)37/h11-12,21-22,26-29,38-39H,2-10,13-20H2,1H3/t22-,26-,27+,28+,29-,30+,41?/m1/s1/i14D2,28D |
| InChIKey | VWUXBMIQPBEWFH-SBFFSMBZSA-N |
| SMILES | [2H][C@]1([C@]2(CC[C@H]3[C@H]([C@@H]2CC1([2H])[2H])[C@@H](CC4=C3C=CC(=C4)O)CCCCCCCCCS(=O)CCCC(C(F)(F)F)(F)F)C)O |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
