FTO-IN-6

• CAT Number: I044154
• CAS Number: 2968347-63-7
• Molecular Formula: C14H12N4O6
• Molecular Weight: 332.27
• Purity: ≥95%
• Synonyms: 2-[[3-hydroxy-6-(4-nitroanilino)pyridine-2-carbonyl]amino]acetic acid
• InChI: InChI=1S/C14H12N4O6/c19-10-5-6-11(17-13(10)14(22)15-7-12(20)21)16-8-1-3-9(4-2-8)18(23)24/h1-6,19H,7H2,(H,15,22)(H,16,17)(H,20,21)
• InChIKey: ITMKUXMZMOBJES-UHFFFAOYSA-N
• SMILES: C1=CC(=CC=C1NC2=NC(=C(C=C2)O)C(=O)NCC(=O)O)[N+](=O)[O-]

FTO-IN-6（Cat No.:I044154）is a selective small-molecule inhibitor of FTO (Fat Mass and Obesity-associated protein), an m6A RNA demethylase involved in epitranscriptomic regulation. By inhibiting FTO, FTO-IN-6 increases N6-methyladenosine (m6A) levels on RNA, affecting mRNA stability, splicing, and translation. It is widely used in cancer and metabolic disease research to explore the role of RNA methylation in gene expression regulation. FTO-IN-6 has shown potential in suppressing tumor cell proliferation and promoting apoptosis, particularly in leukemia and glioblastoma models. This compound is a valuable tool in studying RNA epigenetics and developing FTO-targeted therapeutics.