FTO-IN-3

• CAT Number: I045344
• CAS Number: 2585198-87-2
• Molecular Formula: C12H10N4OS
• Molecular Weight: 258.30
• Purity: ≥95%
• Synonyms: 6-(2-methoxypyrimidin-5-yl)-1,3-benzothiazol-2-amine
• InChI: InChI=1S/C12H10N4OS/c1-17-12-14-5-8(6-15-12)7-2-3-9-10(4-7)18-11(13)16-9/h2-6H,1H3,(H2,13,16)
• InChIKey: POOYWDOOHWPQCU-UHFFFAOYSA-N
• SMILES: COC1=NC=C(C=N1)C2=CC3=C(C=C2)N=C(S3)N

FTO‑IN‑3 (Cat No.: I045344) is a small‑molecule inhibitor of the m⁶A RNA demethylase FTO. It selectively impairs self‑renewal of glioblastoma stem cells in vitro, making it a valuable probe for studying FTO-driven cancer stem cell biology. Used as a research reagent, FTO‑IN‑3 is typically prepared as concentrated DMSO stocks under anhydrous conditions. It enables exploration of FTO’s role in RNA methylation regulation and neural tumorigenesis.

Reference

[1]. Huff S, et al. m6A-RNA Demethylase FTO Inhibitors Impair Self-Renewal in Glioblastoma Stem Cells. ACS Chem Biol. 2021 Feb 19;16(2):324-333.
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