FTO-IN-1 TFA

• CAT Number: I044468
• CAS Number: 2797619-81-7
• Molecular Formula: C20H17Cl2F3N4O4
• Molecular Weight: 505.27
• Purity: ≥95%
• Synonyms: 2-[2,6-dichloro-4-(3,5-dimethyl-1H-pyrazol-4-yl)anilino]-N-hydroxybenzamide;2,2,2-trifluoroacetic acid
• InChI: InChI=1S/C18H16Cl2N4O2.C2HF3O2/c1-9-16(10(2)23-22-9)11-7-13(19)17(14(20)8-11)21-15-6-4-3-5-12(15)18(25)24-26;3-2(4,5)1(6)7/h3-8,21,26H,1-2H3,(H,22,23)(H,24,25);(H,6,7)
• InChIKey: QHFDCFXIEHIDKJ-UHFFFAOYSA-N
• SMILES: CC1=C(C(=NN1)C)C2=CC(=C(C(=C2)Cl)NC3=CC=CC=C3C(=O)NO)Cl.C(=O)(C(F)(F)F)O

FTO-IN-1 TFA（Cat No.:I044468）is the trifluoroacetate salt form of FTO-IN-1, a selective small-molecule inhibitor of the fat mass and obesity-associated protein (FTO), an m6A RNA demethylase. By inhibiting FTO activity, FTO-IN-1 TFA increases N6-methyladenosine (m6A) levels on RNA, affecting gene expression, RNA stability, and splicing. This compound is particularly valuable in cancer and metabolic disease research, where FTO is implicated in tumor progression, chemoresistance, and obesity-related pathways. FTO-IN-1 TFA supports the study of epitranscriptomic regulation and the development of targeted therapies modulating RNA methylation dynamics in disease contexts.