For research use only. Not for therapeutic Use.
FTO-04 (Cat No.: I027817) is a selective inhibitor of the fat mass and obesity-associated protein (FTO), an RNA demethylase involved in epigenetic regulation and metabolic processes. By inhibiting FTO, FTO-04 modulates RNA methylation (m6A), affecting gene expression linked to obesity, cancer, and neurological disorders. It has been studied for its potential in cancer therapy, as FTO overexpression is associated with tumor progression. FTO-04 is a valuable tool in epitranscriptomic research, offering insights into RNA modifications and their role in disease mechanisms.
| Synonyms | FTO-04; FTO04; FTO 04; |
| Molecular Formula | C12H10N4OS |
| Purity | 98% |
| Solubility | Soluble in DMSO |
| Appearance | Solid powder |
| Storage | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| IUPAC Name | 6-(2-methoxypyrimidin-5-yl)benzo[d]thiazol-2-amine |
| InChI | InChI=1S/C12H10N4OS/c1-17-12-14-5-8(6-15-12)7-2-3-9-10(4-7)18-11(13)16-9/h2-6H,1H3,(H2,13,16) |
| InChIKey | POOYWDOOHWPQCU-UHFFFAOYSA-N |
| SMILES | NC1=NC2=CC=C(C3=CN=C(OC)N=C3)C=C2S1 |
| Reference | 1: Huff S, Tiwari SK, Gonzalez GM, Wang Y, Rana TM. m6A-RNA Demethylase FTO Inhibitors Impair Self-Renewal in Glioblastoma Stem Cells. ACS Chem Biol. 2021 Jan 7. doi: 10.1021/acschembio.0c00841. Epub ahead of print. PMID: 33412003. |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
