For research use only. Not for therapeutic Use.
FTI-2153（Cat No.:I006914）is a selective farnesyltransferase inhibitor that blocks the post-translational farnesylation of proteins such as Ras, thereby disrupting membrane localization and downstream oncogenic signaling. By interfering with Ras-driven pathways, FTI-2153 suppresses cell proliferation and survival in tumor cells dependent on aberrant Ras activity. It has demonstrated strong antitumor activity in preclinical models, making it a valuable compound for investigating Ras-mediated oncogenesis and therapeutic intervention strategies. FTI-2153 serves as an important research tool in cancer biology, cell signaling, and targeted drug discovery.
| CAS Number | 344900-92-1 |
| Synonyms | methyl (2S)-2-[[4-[(1H-imidazol-5-ylmethylamino)methyl]-2-(2-methylphenyl)benzoyl]amino]-4-methylsulfanylbutanoate |
| Molecular Formula | C25H30N4O3S |
| Purity | ≥95% |
| IUPAC Name | methyl (2S)-2-[[4-[(1H-imidazol-5-ylmethylamino)methyl]-2-(2-methylphenyl)benzoyl]amino]-4-methylsulfanylbutanoate |
| InChI | InChI=1S/C25H30N4O3S/c1-17-6-4-5-7-20(17)22-12-18(13-26-14-19-15-27-16-28-19)8-9-21(22)24(30)29-23(10-11-33-3)25(31)32-2/h4-9,12,15-16,23,26H,10-11,13-14H2,1-3H3,(H,27,28)(H,29,30)/t23-/m0/s1 |
| InChIKey | KZCMMZOLCBZLNG-QHCPKHFHSA-N |
| SMILES | CC1=CC=CC=C1C2=C(C=CC(=C2)CNCC3=CN=CN3)C(=O)N[C@@H](CCSC)C(=O)OC |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
