Fructosyl-lysine dihydrochloride

• CAT Number: I045491
• CAS Number: 96192-35-7
• Molecular Formula: C12H26Cl2N2O7
• Molecular Weight: 381.25
• Purity: ≥95%
• Synonyms: (2S)-2-amino-6-[[(3S,4R,5R)-3,4,5,6-tetrahydroxy-2-oxohexyl]amino]hexanoic acid;dihydrochloride
• InChI: InChI=1S/C12H24N2O7.2ClH/c13-7(12(20)21)3-1-2-4-14-5-8(16)10(18)11(19)9(17)6-15;;/h7,9-11,14-15,17-19H,1-6,13H2,(H,20,21);2*1H/t7-,9+,10+,11+;;/m0../s1
• InChIKey: IRMWZZYDQZCJMX-YXZYLYLNSA-N
• SMILES: C(CCNCC(=O)C(C(C(CO)O)O)O)CC(C(=O)O)N.Cl.Cl

Fructosyl-lysine dihydrochloride (Cat No.: I045491) is an Amadori product formed by the non-enzymatic glycation of lysine residues with glucose, representing an early intermediate in the Maillard reaction. It serves as a biomarker for protein glycation and oxidative stress, with relevance in diabetes, aging, and food chemistry research. The dihydrochloride salt improves stability and solubility for analytical applications. Fructosyl-lysine dihydrochloride is widely used to study advanced glycation end-product (AGE) formation, assess glycemic control, and investigate the biochemical impacts of protein glycation in health and disease.

Reference

[1]. Rabbani N, et al. Hidden complexities in the measurement of fructosyl-lysine and advanced glycation end products for risk prediction of vascular complications of diabetes. Diabetes. 2015 Jan;64(1):9-11.
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[2]. Karachalias N, et al. Accumulation of fructosyl-lysine and advanced glycation end products in the kidney, retina and peripheral nerve of streptozotocin-induced diabetic rats. Biochem Soc Trans. 2003 Dec;31(Pt 6):1423-5.
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