Frakefamide TFA

• CAT Number: I045888
• Molecular Formula: C32H35F4N5O7
• Molecular Weight: 677.64
• Purity: ≥95%
• Synonyms: (2S)-2-amino-N-[(2R)-1-[[(2S)-1-[[(2S)-1-amino-1-oxo-3-phenylpropan-2-yl]amino]-3-(4-fluorophenyl)-1-oxopropan-2-yl]amino]-1-oxopropan-2-yl]-3-(4-hydroxyphenyl)propanamide;2,2,2-trifluoroacetic acid
• InChI: InChI=1S/C30H34FN5O5.C2HF3O2/c1-18(34-29(40)24(32)15-20-9-13-23(37)14-10-20)28(39)36-26(17-21-7-11-22(31)12-8-21)30(41)35-25(27(33)38)16-19-5-3-2-4-6-19;3-2(4,5)1(6)7/h2-14,18,24-26,37H,15-17,32H2,1H3,(H2,33,38)(H,34,40)(H,35,41)(H,36,39);(H,6,7)/t18-,24+,25+,26+;/m1./s1
• InChIKey: PSUPZYGRMPKCKJ-GWUBCJJCSA-N
• SMILES: C[C@H](C(=O)N[C@@H](CC1=CC=C(C=C1)F)C(=O)N[C@@H](CC2=CC=CC=C2)C(=O)N)NC(=O)[C@H](CC3=CC=C(C=C3)O)N.C(=O)(C(F)(F)F)O

Frakefamide TFA（Cat No.:I045888）is a synthetic peptide derivative belonging to the enkephalin analog class, designed as a selective peripheral μ-opioid receptor agonist. Unlike centrally acting opioids, it does not readily cross the blood–brain barrier, reducing the risk of central nervous system side effects such as addiction or respiratory depression. Supplied as the trifluoroacetate (TFA) salt, it offers stability and solubility for research applications. Frakefamide TFA is mainly used in pain research to explore novel analgesic strategies, opioid receptor signaling, and safer approaches to peripheral pain modulation.