FPFT-2216

• CAT Number: I045152
• CAS Number: 2367619-87-0
• Molecular Formula: C12H12N4O3S
• Molecular Weight: 292.31
• Purity: ≥95%
• Synonyms: 3-[4-(4-methoxythiophen-3-yl)triazol-1-yl]piperidine-2,6-dione
• InChI: InChI=1S/C12H12N4O3S/c1-19-10-6-20-5-7(10)8-4-16(15-14-8)9-2-3-11(17)13-12(9)18/h4-6,9H,2-3H2,1H3,(H,13,17,18)
• InChIKey: SKUSCUALKIOIST-UHFFFAOYSA-N
• SMILES: COC1=CSC=C1C2=CN(N=N2)C3CCC(=O)NC3=O

FPFT-2216（Cat No.:I045152）is a thalidomide-derived “molecular glue” that induces proteasomal degradation of multiple proteins—namely PDE6D, Ikaros (IKZF1), Aiolos (IKZF3), and CK1α—via engagement with CRBN, making it a versatile chemical probe for cancer and inflammatory disease research. In MOLT4 cells, 1 µM FPFT‑2216 (5 h) degrades all four targets; PDE6D degradation occurs within 2 h and persists for at least 24 h, with >50% degradation at just 8 nM and maximal effect by 200 nM. In lymphoma models, FPFT‑2216 activates p53, inhibits NFκB signaling via CK1α degradation, and shows potent antitumor efficacy in vitro and in vivo.