FOXM1-IN-1

• CAT Number: I042378
• CAS Number: 2864407-22-5
• Molecular Formula: C23H30ClNO3
• Molecular Weight: 403.94
• Purity: ≥95%
• Synonyms: N-[2-[2-[4-[(4-chlorophenyl)methoxy]phenoxy]ethoxy]ethyl]cyclohexanamine
• InChI: InChI=1S/C23H30ClNO3/c24-20-8-6-19(7-9-20)18-28-23-12-10-22(11-13-23)27-17-16-26-15-14-25-21-4-2-1-3-5-21/h6-13,21,25H,1-5,14-18H2
• InChIKey: RKTLOUYERGLRCM-UHFFFAOYSA-N
• SMILES: C1CCC(CC1)NCCOCCOC2=CC=C(C=C2)OCC3=CC=C(C=C3)Cl

FOXM1-IN-1 (Cat No.: I042378) is a selective small-molecule inhibitor targeting FOXM1 (Forkhead Box M1), a transcription factor critically involved in cell cycle progression, DNA repair, and tumorigenesis. Overexpressed in various cancers, FOXM1 promotes cancer cell proliferation, metastasis, and therapy resistance. By inhibiting FOXM1, FOXM1-IN-1 downregulates its downstream gene targets, leading to impaired tumor growth and enhanced sensitivity to chemotherapy. This compound is widely used in cancer research to explore FOXM1-driven oncogenic pathways and to evaluate new therapeutic strategies for targeting transcription factor dysregulation.

Reference

[1]. Gao Y, et al. Synthesis and antineoplastic activity of ethylene glycol phenyl aminoethyl ether derivatives as FOXM1 inhibitors. Eur J Med Chem. 2022 Dec 15;244:114877.
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