Fosphenytoin Sodium

  • CAT Number: I006852
  • CAS Number: 92134-98-0
  • Molecular Formula: C16H13N2Na2O6P
  • Molecular Weight: 406.24
  • Purity: ≥95%
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Fosphenytoin (disodium) is the sodium salt form of fosphenytoin, a prodrug that hydrolyzes to phenytoin, which has anticonvulsant properties, upon parenteral administration.If you need, please feel free to contact us, we will reply to you within 24 hours.

Catalog Number I006852
CAS Number 92134-98-0
Molecular Formula


Purity 95%
Target PDE3 inhibitor
Solubility Soluble in DMSO, not in water
Storage 2-8°C
IUPAC Name disodium;(2,5-dioxo-4,4-diphenylimidazolidin-1-yl)methyl phosphate
InChI InChI=1S/C16H15N2O6P.2Na/c19-14-16(12-7-3-1-4-8-12,13-9-5-2-6-10-13)17-15(20)18(14)11-24-25(21,22)23;;/h1-10H,11H2,(H,17,20)(H2,21,22,23);;/q;2*+1/p-2
SMILES C1=CC=C(C=C1)C2(C(=O)N(C(=O)N2)COP(=O)([O-])[O-])C3=CC=CC=C3.[Na+].[Na+]

</br>1:Relative bioavailability of orally administered fosphenytoin sodium injection compared with phenytoin sodium injection in healthy volunteers. Kaucher KA, Acquisto NM, Rao GG, Kaufman DC, Huntress JD, Forrest A, Haas CE.Pharmacotherapy. 2015 May;35(5):482-8. doi: 10.1002/phar.1589. PMID: 26011141 </br>2:Bioavailability of intravenous fosphenytoin sodium in healthy Japanese volunteers. Inoue Y, Usui N, Hiroki T, Shimizu K, Kobayashi S, Shimasaki S.Eur J Drug Metab Pharmacokinet. 2013 Jun;38(2):139-48. doi: 10.1007/s13318-012-0105-x. Epub 2012 Sep 12. PMID: 22968854 Free PMC Article</br>3:Population pharmacokinetics of phenytoin after intravenous administration of fosphenytoin sodium in pediatric patients, adult patients, and healthy volunteers. Tanaka J, Kasai H, Shimizu K, Shimasaki S, Kumagai Y.Eur J Clin Pharmacol. 2013 Mar;69(3):489-97. doi: 10.1007/s00228-012-1373-8. Epub 2012 Aug 24. PMID: 22918614 Free PMC Article</br>4:Fosphenytoin sodium: new drug to replace intravenous phenytoin sodium. Voytko SM, Farrington E.Pediatr Nurs. 1997 Sep-Oct;23(5):503-6. No abstract available. PMID: 9355589 </br>5:Stability of fosphenytoin sodium with intravenous solutions in glass bottles, polyvinyl chloride bags, and polypropylene syringes. Fischer JH, Cwik MJ, Luer MS, Sibley CB, Deyo KL.Ann Pharmacother. 1997 May;31(5):553-9. PMID: 9161647 </br>6:Safety of fosphenytoin sodium. Fierro LS, Savulich DH, Benezra DA.Am J Health Syst Pharm. 1996 Nov 15;53(22):2707-12. Review. PMID: 8931812

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