For research use only. Not for therapeutic Use.
Fosgonimeton (Cat No.: I027722) is an investigational small-molecule prodrug developed to enhance synaptic function and cognitive performance in neurodegenerative diseases, particularly Alzheimer’s disease. It is metabolized into the active compound ATH-1001, which positively modulates the hepatocyte growth factor (HGF)/MET signaling pathway, promoting neuronal survival, regeneration, and synaptic plasticity. Fosgonimeton is designed to improve memory, attention, and executive function. Currently in clinical trials, it holds promise as a novel therapeutic approach for treating cognitive impairment and neurodegeneration.
| CAS Number | 2093305-05-4 |
| Synonyms | [4-[(2S)-3-[[(2S,3S)-1-[(6-amino-6-oxohexyl)amino]-3-methyl-1-oxopentan-2-yl]amino]-2-(hexanoylamino)-3-oxopropyl]phenyl] dihydrogen phosphate |
| Molecular Formula | C27H45N4O8P |
| Purity | ≥95% |
| InChI | InChI=1S/C27H45N4O8P/c1-4-6-8-12-24(33)30-22(18-20-13-15-21(16-14-20)39-40(36,37)38)26(34)31-25(19(3)5-2)27(35)29-17-10-7-9-11-23(28)32/h13-16,19,22,25H,4-12,17-18H2,1-3H3,(H2,28,32)(H,29,35)(H,30,33)(H,31,34)(H2,36,37,38)/t19-,22-,25-/m0/s1 |
| InChIKey | MBYDCPOKVKDSFD-JTJYXVOQSA-N |
| SMILES | CCCCCC(=O)NC(CC1=CC=C(C=C1)OP(=O)(O)O)C(=O)NC(C(C)CC)C(=O)NCCCCCC(=O)N |
| Reference | [1]. WO2017210489 |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
