Forskolin - CAS 66575-29-9

Forskolin(Colforsin) is a labdane diterpenoid with antihypertensive, positive inotropic, platelet aggregation inhibitory and adenylate cyclase activating properties.
IC50 Value: 0.5 uM (EC50)
Target: Adenylate cyclase
in vitro: Forskolin (10 microM) rapidly increased cAMP levels in bovine thyroid slices both in the absence and presence of a phosphodiesterase inhibitor. The effect of TSH (50 mU/ml) on cAMP levels was additive or greater than additive to that of forskolin [1]. Fsk treatment of MT-2 and Kit 225 T-cells inhibited IL-2-induced Stat5a/b tyrosine and serine phosphorylation, nuclear translocation, and DNA binding activity. Fsk treatment also uncoupled IL-2 induced association of the IL-2Rβ and γc chain, consequently blocking Jak3 activation [2].
in vivo: Low concentrations of forskolin (0.1-1.0 microM), which significantly elevated cyclic AMP levels, did not increase lipolysis, whereas similar increases in cyclic AMP levels due to isoproterenol elevated lipolysis. Forskolin did not inhibit the activation of triacylglycerol lipase by cyclic AMP-dependent protein kinase or the subsequent hydrolysis of triacylglycerol [3]. Colforsin-induced vasodilation was impaired in both +E and -E arteries from PH rats compared with their respective controls. Endothelial removal did not influence colforsin-induced vasodilation in the arteries from control rats, but attenuated it in arteries from PH rats [4].
Clinical trial: N/A

Catalog Number: I004502

CAS Number: 66575-29-9

PubChem Substance ID:355049822

Molecular Formula: C22H34O7

Molecular Weight:410.5

Purity: ≥95%

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Synonym

Synonyms	[(3R,4aR,5S,6S,6aS,10S,10aR,10bS)-3-ethenyl-6,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-1-oxo-5,6,6a,8,9,10-hexahydro-2H-benzo[f]chromen-5-yl] acetate

Property

Molecular Formula:	C22H34O7
Molecular Weight	410.5
Target:	Adenylate cyclase
Solubility	10 mM in DMSO
Purity	≥95%
Storage	3 years -20C powder
IC50	0.5 uM (EC50)

Computed Descriptor

InChIKey	OHCQJHSOBUTRHG-KGGHGJDLSA-N