Fontolizumab

• CAT Number: I042422
• CAS Number: 326859-36-3
• Purity: ≥95%

Fontolizumab (Cat No.: I042422) is a humanized monoclonal antibody that targets interferon-gamma (IFN-γ), a key cytokine involved in immune activation and inflammation. By neutralizing IFN-γ, fontolizumab reduces inflammatory responses, making it a potential therapeutic for autoimmune and inflammatory diseases such as Crohn’s disease and rheumatoid arthritis. It has been evaluated in clinical trials for its ability to modulate Th1-driven immune responses. Fontolizumab offers a targeted immunosuppressive approach aimed at mitigating chronic inflammation without broadly suppressing the immune system.

Reference

[1]. Hommes DW, et, al. Fontolizumab, a humanised anti-interferon gamma antibody, demonstrates safety and clinical activity in patients with moderate to severe Crohn’s disease. Gut. 2006 Aug;55(8):1131-7.
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